Phenoxyacetophenone could be prepared from potassium phenolate and m bromoacetophenone via Ullmann reaction catalyzed by copper acetate in high yields.
The invention is applied to the catalytic reactions such as aromatic ketone unsymmetrical hydrogen transfer reaction and can achieve very high yield and enantiotropic selectivity.
P-Brom-ethylphene was prepared by brom-phene by means of Friedel-Crafts and Huang Ming-long reactions. The synthesis can be industrialized because of good quality, high yield and low cost.
This method not only lowcrs the temperature of labelling ortho-iodo-hippuric acid, speeds up the reaction and gives high yield, but aslo suits the requirement of large scale production.