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Despite advances in the diagnosis and treatment of the antineutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitides, renal morbidity is common.

虽然对于抗中粒细胞胞浆抗(ANCA)血管的诊疗有较大的进展,但是肾脏的损害依然很严重。

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Osmosis-神经

In addition, plasmapheresis can be effective as well, which is when the plasma is filtered to remove disease-causing autoantibodies.

另外,血浆置换也有效果,通过过滤血浆移除导致疾病自身抗体。

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Osmosis-肌骨

But unlike many other autoimmune conditions, no autoantibody has been specifically linked to the disease.

和其他自身免疫病不同,至今尚未发现和该病特异性相关自身抗体。

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Osmosis-泌尿

One way these complexes can form is as a result of autoantibodies directly targeting the glomerular basement membrane.

这些复合物形成之一是自身抗体接攻击肾小球基

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This condition is actually an autoimmune disease in which autoantibodies target natively produced proteins, some of which are secreted by cartilage cells.

这种情况实际是自身免疫性疾病,自身抗体靶向正常产生蛋白质,有些蛋白质是软骨细胞分泌

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Osmosis-肌骨

Spondyloarthropathies are all autoimmune diseases that affect the joints, and they're seronegative, which refers to the fact that rheumatoid factor, which is an autoantibody, is not found in the blood.

脊柱关节病是一类累及关节、且血清学呈阴性自身免疫病;血清学阴性是指患者血液中未发现类风湿因子这种自身抗体。

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Osmosis-泌尿

The rest of cases, though, are secondary, and seem to arise from autoantibodies that are generated in response to another process like an infection, malignancies, autoimmune conditions, or medications.

另一种病因是继发性,自身抗体来源于对机体其他疾病应答,如感染,恶性肿瘤,自身免疫状态或药物等。

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Osmosis-神经

In very rare cases, myasthenia gravis can present as a paraneoplastic syndrome, which means that an underlying cancer like bronchogenic carcinoma or thymic neoplasm (also known as thymoma) generates an immune response which results in generation of autoantibodies.

在极罕见情况下,重症肌无力会表现出副肿瘤综合征,这意味着潜在癌症如支气管肺癌、胸腺肿瘤导致免疫应答产生了自身抗体。

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