CONCLUSION The QSAR model can predict the MIC of carbapenems and select the biologic-activity compounds, which offer a new way of thinking and references of carbapenems compounds design.
结论所建立QSAR模型能有效地进行碳青霉
MIC
预测和
筛选,为这
新药开发提供新
参考和思路。
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It's a multidrug resistant bacteria, and it can be treated with cephalosporins, aminoglycosides, fluoroquinolones, and carbapenems in case of beta-lactamase production; only with carbapenems in case of ESBL production; and with colistin, tigecycline or fosfomycin in case of carbapenemases production.
肺炎克雷伯杆也是一种多重耐药
,如果产生β-内酰胺酶,可以用头孢
素、氨基
、氟喹诺酮
以及碳青霉烯
药
治疗;如果产生ESBL,可以只应用碳青霉烯
进行治疗;如果产生碳青霉烯酶,则应用多粘
素、替加环素或磷霉素进行治疗。