This paper reports the improvement on the synthesis of 5 methylisoxazol 3 formamide by Claisen condensation of diethyl oxalacetate followed by cyclization and ammonolysis.
Entomologist Stephen Doggett, who runs the NSW Health arbovirus program which monitors mosquitoes and the diseases they carry is firmly in the DEET (diethyl toluamide) camp.
The synthesis of tridecane dicarboxylic acid diethyl ester with ethyl alcohol and tridecane dicarboxylic acid as reactants and cation exchange resin as catalyst had been studied.