KGF can specifically stimulate the epithelial mitogenesis and regulate the interaction of mesenchyma and epithelia,so it has broad biological functions.
Objective: To investigate the relationship of angiogenesis and microvessel density(MVD) with non-neoplastic epithelial disorders of the vulva(NNEDV) and valvar intraepithelial neoplasia(VIN).
In mice, widespread deletion of the tumor suppressor Phosphatase and tensin homolog (PTEN) generates hamartomatous intestinal polyps with epithelial and stromal inolement.