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In addition, only certain murine mAb isotypes hae been shown to effectiely bind to and actiate elements of the human immune system, thereby triggering cytotoxic effector functions10.

另外,只有某些亚型鼠单抗可合并激活人免疫系统,激发细胞毒作用[10]。

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科学60秒-科学美国人 202210

So most of the mabs don't fit anymore.

大多数 mab 不再管用了。

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科学60秒-科学美国人 202210

Look, I don't want to keep tossing out problems, but mabs aren't a pill like Paxlovid.

不是我想不停提问,但 mab 不是 Paxlovid 那

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科学60秒-科学美国人 202210

To go broad. Scientists used to pick these mabs based on how strongly they attached to a particular virus.

扩大范围。以前,科学家们依据 mab 对特定病毒的附着强度来挑选

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科学60秒-科学美国人 202210

Not yet. There are about 10 of these mabs in various stages of testing.

还不行。现在有 10 余 mab 正处于不同阶段测试中。

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科学60秒-科学美国人 202210

In plain English that means spots that don't mutate from variant to variant, so the mabs can still lock on.

说白了就是那块区域不会随变异株而变异,继而 mab 能一直锁定病毒。

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科学60秒-科学美国人 202210

Another advantage mabs have is they can be used to prevent infection in people who are in high-risk situations.

Mab 的另一优势是可用于预防高风险人群被感染。

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科学60秒-科学美国人 202210

It turns out, though, that mabs are actually cheap to produce these days, just one or two hundred bucks a pop.

但事实上,mab 现在的生产成本很低——每剂只有一两百美元。

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科学60秒-科学美国人 202210

They've usually got long, difficult names, but they typically end in " mab, " so that's the giveaway.

这些新的名字一般都很长很难懂,但通常都以“mab(单克隆抗体)”结尾,因此这透露了品配方。

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科学60秒-科学美国人 202210

Some may be immunocompromised and don't get much benefit from vaccines, so mabs can play a prevention role for them.

其中一些人可能有免疫缺陷,他们打疫苗得不到多少益处,因此 mab 便可以保护他们。

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科学60秒-科学美国人 202210

These mabs were configured to fit that early virus, like a key fitting into a lock.

这些 mab 是为早期病毒量身打造的,就像为一把锁配的钥匙。

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科学60秒-科学美国人 202210

I saw a study in which scientists tested 21 different " mabs" against the BA. 4 and 5 variants, and only one was able to neutralize them.

我看过一项研究,说科学家们测试了 21 mab 对抗 BA.4 和 BA.5 变异的情况,只有一能中和病毒。

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