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Randomized aldactone evaluation study (RALES) showed that adding aldosterone antagonist in the treatment of heart failure may decrease 30% mortality of all causes.

随机评估研究表明在心力衰竭治中加用醛甾酮拮抗药可使总降低30%。

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make as if, make believe, make demands of, make demands on, make do with, make do with sth, make ends meet, make faces, make for, make for sb,

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Osmosis-心血管

Another example is a tumor that produces excess aldosterone, which just like renin, leads to fluid retention.

另一个例子是肿瘤生长也会产生过多醛固酮一种类似于肾素物质,会导致液体积存。

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Osmosis-内分

With these medications around, aldosterone can't exert its effects.

有了这些药物,醛固酮就无法发挥作用了。

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Osmosis-

An important hormone that helps regulate potassium reabsorption or secretion in the kidneys is aldosterone.

肾脏中一种帮助调节钾重吸收或分重要激素叫醛固酮

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WIL生活

This suggests that people actually following the WHO guidelines are chronically raising their aldosterone.

也就是说,遵循世卫组织关于盐摄入量建议人们,他们体内醛固酮长期处于较高水平

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Osmosis-

Other pathological conditions that cause increased aldosterone levels include compensated heart failure and cirrhosis.

他导致醛固酮水平增加病理状况包括代偿期心衰和肝硬化。

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Aldosterone has it's purpose, but it's not a hormone you want to regularly have high levels of.

醛固酮有作用,但在人体中,这种荷尔蒙水平不能太高。

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Osmosis-内分

The diagnosis of hyperaldosteronism is mainly done by measuring levels of renin and aldosterone.

醛固酮增多症诊断主要通过测定肾素与醛固酮水平来完成

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Osmosis-内分

Aldosterone is part of a hormone family or axis which work together and are called the renin-angiotensin-aldosterone system.

醛固酮属于一特定激素家族或激素轴一部分,这些激素共同作用,被称为肾素-血管紧张素-醛固酮系统。

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But, as I mentioned earlier, this renin angiotensin aldosterone system is stimulated by low salt intake.

但是,正如我之前提到,低盐饮食会导致 RAA 系统活跃。

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Osmosis-

Now, an important hormone that helps regulate potassium reabsorption or secretion in the kidneys is aldosterone.

所以,肾脏中有一种重要激素可以帮助调节钾重吸收和分,这就是醛固酮

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Osmosis-内分

So in this case aldosterone levels are high and renin levels are low in.

因此,在这种情况下,醛固酮水平较高,肾素水平较低。

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Osmosis-内分

Secondary causes of hyperaldosteronism are usually due to excess aldosterone production in response to high levels of renin.

醛固酮增多症继发性原因通常是由于高水平肾素导致醛固酮生成过多。

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As this study shows, a low salt diet increases aldosterone by more than 3 fold in healthy people.

这项研究显,健康正常人采用低盐饮食,体内醛固酮水平将增加 3 倍有余。

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High aldosterone is associated with increased inflammation, Chronic kidney disease, Osteoporosis, and cardiovascular disease.

醛固酮水平会增加体内炎症,导致慢性肾病、骨质疏松症以及心血管疾病。

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WIL生活

These drugs inhibit Angiotensin Converting Enzyme, hindering an important step in the RAA system resulting in lower aldosterone and lower blood pressure.

这种药物通过抑制血管紧张素转化酶作用(RAA 系统关键作用之一),以达到降低醛固酮水平及血压

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Osmosis-内分

Hyperaldosteronism can happen due to primary causes which is where the adrenal gland itself is responsible for the excess production of aldosterone.

醛固酮增多症可以是原发性,即肾上腺本身产生了过量醛固酮

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WIL生活

On the flip side of aldosterone, there is a group of hormones called natriuretic hormones, i. e. sodium urinating hormones.

醛固酮另一面有一组激素叫利钠激素,也就是钠荷尔蒙。

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WIL生活

Another study shows that when salt intake drops below 1.5 teaspoons per day, a significant increase in renin and aldosterone occurs.

另一项研究显,当盐摄入量降至每天 1.5 茶匙以下,人体中醛固酮及肾素水平将大幅上升。

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Osmosis-

Aldosterone increases sodium channels on the lumen side of the principal cell and sodium-potassium pumps on the basolateral side of the principal cells.

它增加主细胞腔面钠离子、钾离子通道和基底面钠-钾泵数量。

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Osmosis-内分

Less aldosterone floating around in the blood causes the body to start dumping sodium from the blood into the urine.

血中醛固酮减少使得钠排出增多。

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