34-36 A concern for patients with BM treated with antiangiogenic therapies has been intracranial hemorrhage (ICH).

34-36 对于接受抗血管生法治的 BM 患者来说，一个令人担忧的问题是颅内出血 (ICH)。

Antiangiogenic agents have shown modest additional benefits when added to chemotherapy in both the first- and second-line settings, including in patients with BM.

在一线和二线治（包括 BM 患者）将抗血管生药物添加到化时，已显示出适度的额外益。

Combinations of EGFR-TKIs and other types of agents have been investigated in the first-line setting, such as antiangiogenic agents (bevacizumab and ramucirumab) combined with erlotinib.

EGFR-TKI 他类型药物的组合已在一线环境进行了研究，例如抗血管生药物（贝伐珠单抗和雷莫芦单抗）厄洛替尼的组合。