Obesity and metabolic syndrome are recognized as strong risk factors for hand OA, but also knee OA, where low-grade chronic inflammation and systemic metabolic alterations disrupt joint tissue homoeostasis.

肥胖和代谢综合征被认为是手部骨节炎的强风因素，同时也是膝节骨节炎的风因素，在这些情况，别的慢性炎症和全身代谢改变会扰乱节组织的稳态。