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Testicular allotransplantation is one of the effective options for the treatment of male infertility and hypogonadism.

异体是治疗男性不育或性腺功能减退方法之一

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Methods 4 patients underwent testis homotransplantion with their relatives testis as donor tissue.Of them, 2 suffered from iatrogenic anorchia and the other 2 from hypogonadism.

方法利用亲属作供体行同种异体4例,其中医源性无症2例,原发性性腺机能低下2例,术后观察患者血清酮水平、第二性征变化及性功能情况

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Osmosis-生殖

Next, endocrine dysfunctions that causes testosterone levels to fall, like hypogonadism, can cause erectile dysfunction.

其次,内分泌功障碍导致睾酮水平降,如性腺减退会导致勃起功障碍。

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Osmosis-内分泌

Some acquired causes of primary hypogonadism are radiation therapy, chemotherapy, and trauma to the gonads.

可引起原发性性腺减退症的获得性有放疗、化疗和性腺创伤。

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Osmosis-内分泌

Some congenital causes of primary hypogonadism are genetic diseases like Klinefelter or Turner syndrome.

可引起原发性性腺减退的先天包括Klinefelter合征或Turner合征等遗传病。

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Osmosis-遗传

These streak ovaries can't produce sex hormones, resulting in hypogonadism and low estrogen levels.

这些条索状卵巢无法产生性激,导致性腺、雌激水平

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Osmosis-内分泌

Some acquired causes are similar to primary hypogonadism, radiation therapy, chemotherapy, and trauma to the gonads.

有些获得性与原发性性腺减退症相似,也包括放疗、化疗和性腺创伤。

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Osmosis-内分泌

Because of this, Kallmann syndrome is a type of hypogonadotropic hypogonadism disorder.

如此,Kallmann合征是一种促性腺激性性腺功减退症。

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Osmosis-内分泌

There are two main causes of hypogonadism.

性腺减退有两个主要病

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Osmosis-内分泌

Blood tests of hormone levels can give an idea of the type of hypogonadism.

血液激水平的检测可以为性腺减退的类型提供参考

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Osmosis-内分泌

So, to recap: Kallmann syndrome is a type of hypogonadotropic hypogonadism where olfactory neurons and gonadotropin-releasing hormone neurons don't function normally.

Kallmann合征是一种促性腺激性腺减退症,其嗅觉神经元与促性腺激释放激神经元不发挥正常功

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Osmosis-内分泌

This is called hypergonadotropic (because the level of gonadotropins are high) hypogonadism (because the level of gonad or ovarian hormones is low).

由于促性腺激水平高,而性腺或卵巢激水平,这被称为高促性腺激型性腺功减退症

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Osmosis-内分泌

This leads to an overproduction of luteinizing and follicle stimulating hormones, so primary hypogonadism is also called hypergonadotropic hypogonadism.

这会导致LH和FSH生成过多,所以原发性性腺功减退症也称为高促性腺激性性腺功减退症。

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Osmosis-内分泌

Though there are different causes which result in different levels of gonadotropin hormones, they all ultimately result in hypogonadism and a deficiency in testosterone or estrogen and progesterone.

尽管青春期延迟的病很多,会导致促性腺激水平各不相同,但最终的结果都是性腺减退以及男性睾酮或女性雌激和孕酮的缺乏。

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Osmosis-内分泌

Just like in secondary hypogonadism, there's a lack of gonadotropin-releasing hormone, but the key difference is that it's not considered pathologic - instead, it's thought to be a naturally slowed rate of maturation.

与继发性性腺减退症类似也存在GnRH的缺乏,但关键的区别在于这种缺乏不是病理性的,而是一种正常的发育延迟。

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Osmosis-内分泌

Secondary hypogonadism can be due to hypothalamus or pituitary gland dysfunction; either from an inability to produce gonadotropin-releasing hormone or luteinizing and follicle stimulating hormones, or suppression from other hormones, like prolactin or thyroid hormone.

继发性性腺减退症可由丘脑或垂体功障碍导致,既可是促性腺激释放激、黄体生成和卵泡刺激的生成,也可是以上激的分泌受到了其他激的抑制,例如泌乳或甲状腺激

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Osmosis-内分泌

The second cause of hypogonadism is secondary hypogonadism, which is also called hypogonadotropic hypogonadism because there are low levels of luteinizing and follicle stimulating hormones.

性腺功减退的第二个病是继发性性腺功减退症,也称为促性腺性性腺功减退症,为LH和FSH激水平在此病中都显著降

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Osmosis-内分泌

The first is primary hypogonadism which is caused by dysfunction of the gonads - for example, the gonad's receptors may not respond to gonadotropin hormones, or the gonads might not have healthy cells that are capable of producing hormone.

一是原发性性腺减退,由性腺功障碍引起,例如,性腺受体对促性腺激不敏感或者性腺内没有够产生性激的健康细胞。

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