Streptomyces

Objective To improve the production of clavulanic acid and to genetically delete cephamycin C in the fermentation of Streptomyces clavuligerus.

目提高棒状链菌克拉维酸产能力,去除副产C。

Method Bifidobacterium plasmid was extracted by mutanolysin from Streptomyces globisporus which could lyse the wall of bifidobacterium.The result was compared with that by lysozyme.

方法利用球孢链菌发酵产变溶菌来消化双歧杆菌细胞壁，提取质粒，并与商业化溶菌酶法比较。