fluorouracil

Doxifluridine was facilely synthesized from 5-fluorouracil in overall yield of 54.6% via trimethyl silylation, condensation, saponification, ketal formation, iodation, hydrogenolysis and hydrolysis.

5-嘧啶为原经硅醚化、酰核糖缩合、皂化、酮缩醇形成、碘化、氢解及水解等反应合成了去氧苷。本法工艺简便、条件缓、原易得、成本低,总收率达54.6

Purpose: Options for single-agent fluoropyrimidine adjuvant therapy after bowel cancer resection include intravenous fluorouracil with leucovorin (FU/LV) or oral capecitabine.

目的：肠道肿瘤切除术后脲嘧啶类单药辅助化疗可选氢叶酸联合嘧啶持续静脉灌注（FU/LV）或者口服卡培它滨。